Applications for our technology
Gene Editing
Patients are waiting for our breakthroughs. Could we help you develop safe and effective treatments faster?
Defying conventional wisdom to find new therapeutic opportunities
In the last two decades, we have witnessed spectacular progress in gene editing technologies. The ingenuity encoded in the natural microbial world continues to surprise us with every new discovery. Our challenge now is to harness them into therapies that deliver real-world benefits.
2012
first demonstration of CRISPR in mammalian cells
100+
active clinical trials for CRISPR and next-generation gene editing therapies now
Beyond catalogues and databanks
Discovering and designing next-generation gene editors
We systematically map the planet's genomes, proteins and in situ environmental and chemical conditions. Through this biodiscovery process, we help our partners draw on vastly more natural starting points and genomic insights to design diverse gene editing systems that can open up novel therapeutic avenues.
Partner with us to develop and license our novel gene editors.
Send us a messagePartner with us to develop and license our novel gene editors.
Superior insight from superior diversity
Expanding the repertoire of recombinases by 30x for large human genome insertions
Moving beyond edits, recent discoveries have enabled ‘gene writing’ technology, that is the insertion of large DNA ‘cargos’ into host genomes. One phage system that accomplishes this is mediated by large serine recombinases (LSRs).
Using our purpose-built knowledge graph, we uncovered orders of magnitude more LSRs compared to public data. Crucially, this enabled us to map novel LSRs to over 20,000 integration sites in cis, which is key in utilising this system for therapeutic applications.
Read more on our blogUsing our purpose-built knowledge graph, we uncovered orders of magnitude more LSRs compared to public data. Crucially, this enabled us to map novel LSRs to over 20,000 integration sites in cis, which is key in utilising this system for therapeutic applications.
IP ownership
Gain freedom to operate with more diverse gene editors from nature
Bespoke solutions
Match the best gene editing components to your target indications
Access to novelty
Rapidly ideate across nucleases, RTs, recombinases, and more
Partner with us
See how we can help with your target enzymes and applications
We partner with people all across the bioeconomy, including agritech, food, API manufacture, cosmetics & more.
So whether you're a synthetic biologist developing living therapeutics, a metabolic engineer enhancing biofuel production, or an enzymologist designing biocatalysts for bioplastics, give us a shout!
So whether you're a synthetic biologist developing living therapeutics, a metabolic engineer enhancing biofuel production, or an enzymologist designing biocatalysts for bioplastics, give us a shout!
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Rooted in Access and Benefit Sharing
Future-proofed data collection
At the heart of our biodiscovery process is a our commitment to Access and Benefit Sharing (ABS). ABS is a cornerstone principle of the Convention on Biological Diversity and its Nagoya Protocol, which seeks to ensure fair and equitable sharing of benefits arising from the utilisation of genetic resources.
We're building a robust model for long term biodiversity protection through our global sampling partnerships. Each of our samples is collected in compliance with the Nagoya Protocol and with pre-negotiated permission to commercialise with our industry partners. Our aim is to create a world where industrial innovation protects, supports and revitalises our natural biodiversity.
We're building a robust model for long term biodiversity protection through our global sampling partnerships. Each of our samples is collected in compliance with the Nagoya Protocol and with pre-negotiated permission to commercialise with our industry partners. Our aim is to create a world where industrial innovation protects, supports and revitalises our natural biodiversity.