EDEN designs recombinases (LSRs) that can insert long, complex DNA payloads at safe, predictable and well defined genomic sites, without double stranded breaks. These small proteins can easily be delivered in vivo via LNPs and/or AAVs.

We design novel gene editing systems that enable a wide range of edits, from simple gene knockout to targeted, high fidelity insertion of large, complex DNA.

EDEN designs and optimises proteins and peptides across disease areas, combining low sequence identity to marketed molecules with defined developability metrics and demonstrated efficacy in animal models.